使用湿球磨砂制备和评估可吸入的阿米福斯微粒
Jae-Cheol Choi1, Ji-Hyun Kang2, Dong-Wook Kim3
1College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea.
Pharmaceutics
|June 28, 2023
概括
这项研究开发了可吸入的amifostine (AMF) 微粒,用于肺部输送. 与极性溶剂相比,使用非极性溶剂进行湿球磨削可以获得优越的微粒特性和吸入效率.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 乙醇 (amifostine) 传统上是在溶解后静脉注射的.
- 肺部药物输送提供了提高疗效和减少全身副作用的潜力.
- 开发稳定且有效的可吸入的amifostine微粒对于这种输送途径至关重要.
研究的目的:
- 开发可吸入的阿米福斯微粒 (AMF).
- 为了比较通过喷气削和湿球削制备的AMF微粒的物理化学特性和吸入效率.
- 评估不同溶剂 (极性与非极性) 对微粒子特性的影响.
主要方法:
- 使用喷气削和湿球削来制备阿米福斯微粒.
- 湿球研磨涉及在不钢中将AMF与球和溶剂 (甲醇,乙醇,,烯) 混合.
- 评估了物理化学性质和空气动力学特性 (例如,微粒分数的百分比).
主要成果:
- 喷气削产生了26.9%的微粒分数 (FPF).
- 使用极性溶剂 (甲醇,乙醇) 进行湿球磨削,导致% FPF值分别为34.5%和27.9%.
- 使用非极性溶剂 (,) 的湿球磨粉实现了更高的% FPF值,分别为45.5%和44.7%.
- 非极性溶剂产生了更加均和稳定的晶体AMF微粒.
结论:
- 湿球是一种有效的方法,用于制备可吸入的amifostine微粒.
- 非极性溶剂显著增强了阿米福斯微粒的空气动力学特性和晶体稳定性.
- 这种优化的配方有望为阿米福斯的有效的肺输送提供希望.
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