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四种生物活性酸基水泥的物理化学,生物和抗菌特性
Yu-Ji Jang1, Yu-Jin Kim2, Huong Thu Vu3
1Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandaero, Cheonan 31116, Republic of Korea.
Pharmaceutics
|June 28, 2023
概括
这项研究比较了四种基于酸的水泥 (CSC),发现预混合型在物理和抗菌特性方面优越. 预混合的Endocem® MTA (ECPR) 显示出最佳的抗菌活性,尽管在低度下,生物差异是最小的.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 恢复性牙科 恢复性牙科
背景情况:
- 基于酸盐的水泥 (CSC) 在牙科中对于纸治疗至关重要,因为它具有生物相容性和密封性.
- 目前的CSC有诸如长时间设置和处理不良等局限性.
- 最近的进展旨在改善CSC的临床特性,需要进行比较研究.
研究的目的:
- 为了比较四种商业 CSC 的物理化学,生物和抗菌性质.
- 评估两个粉液混合型 (RetroMTA®,Endocem® MTA Zr) 和两个预混合型 (Well-RootTM PT,Endocem® MTA预混合).
- 确定用于临床应用的CSC配方的潜在改进.
主要方法:
- 测试了四种商业CSC:两种粉液 (RETM,ECZR) 和两种预混合 (WRPT,ECPR).
- 评估了物理化学性质 (表面,流动性,薄膜厚度,pH值).
- 评估了生物效应 (细胞活力,口腔细胞分化) 和抗菌活性.
主要成果:
- 与粉末-液体类型相比,预混合的CSC显示出更高的表面均性,流动性和更低的薄膜厚度.
- 所有CSC均保持pH值在11.5至12.5之间.
- 在25%的度下,Endocem® MTA Zr (ECZR) 显示出更高的细胞活力和口腔细胞分化.
- 预混合的CSC表现出增强的抗菌活性,ECPR显示出最佳性能.
- 在12.5%度下没有观察到显著的生物差异.
结论:
- 预混合的CSC提供了比传统的粉末液体配方更好的物理性能.
- 在测试材料中,Endocem® MTA预混合 (ECPR) 显示出显著的抗菌潜力.
- 虽然ECZR在生物评估中表现有前途,但在较低度下并不总是观察到显著差异.
- 由于其强大的抗菌疗效,ECPR是临床使用的有希望的候选者,需要进一步研究.
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