上鼻腔:系统性药物输送,粘膜疫苗和"鼻至脑"的选择
1Formerly of Impel Pharmaceuticals, 201 Elliott Ave West, Seattle, WA 98119, USA.
Pharmaceutics
|June 28, 2023
概括
鼻腔药物输送对疫苗和直接大脑治疗有希望. 先进的输送设备可以针对上鼻腔空间进行更好的吸收,从而有可能加速药物和疫苗的开发.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
- 药物输送系统 药物输送系统
背景情况:
- 鼻腔粘膜作为阻碍全身药物吸收的障碍.
- 非侵入性鼻腔药物输送已经实现了小分子的良好生物可用性.
- 随着COVID大流行,人们越来越关注用于粘膜免疫的鼻腔疫苗.
研究的目的:
- 探索向的鼻腔药物输送以提高吸收.
- 为了研究鼻腔在接种疫苗方面的潜力.
- 为了确定直接鼻到脑药物输送的策略.
主要方法:
- 审查当前的鼻腔药物递送技术.
- 对不同鼻腔区域药物沉积的分析.
- 评估用于准上鼻腔空间的输送设备.
主要成果:
- 准鼻腔上部的嗅觉上皮质可以增强药物吸收.
- 在上鼻腔空间的非运动性乳毛和减少的粘膜清除增加了停留时间.
- 输送装置,而不仅仅是复杂的配方,可以实现有针对性的鼻腔输送.
结论:
- 优化鼻腔药物输送装置可以改善系统性和直接的中枢神经系统吸收.
- 有针对性的鼻腔输送为药物和疫苗开发提供了更快,更有效的途径.
- 鼻腔为新型治疗和免疫提供了可行的途径.
关键词:
在OptiNose®上,您可以使用OptiNose.精确的嗅觉传递 (POD®) 技术通过ViaNase®获得了成功.血脑屏障 (BBB) 是一个中枢神经系统 (CNS)鼻内输送是指鼻内输送.鼻腔传递是通过鼻子进行的.鼻子到大脑 (N2B) 的连接嗅觉上皮质是一种嗅觉上皮质.上鼻腔空间的上部部分.更多相关视频
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