生物复合材料用于长时间释放水溶性药物
Lyghia M A Meirelles1, Raquel de Melo Barbosa1,2, Renato Ferreira de Almeida Júnior3
1Laboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Pharmaceutics
|June 28, 2023
概括
这项研究开发了一种新的奇托桑-帕利戈尔斯基特系统,用于长时间释放乙醇,改善结核病药物稳定性并减少湿透性. 天然复合微粒显示出出色的封装和生物相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物技术是生物技术.
背景情况:
- 结核病治疗需要稳定的药物配方,但乙醇 (ETB) 呈现出高透性和药物不相容性.
- 天然,负担得起的材料,如合石和酸盐,为开发改进的药物输送系统提供了潜力.
研究的目的:
- 开发一种使用合石和酸盐复合物的长期释放乙醇系统.
- 评估开发的微粒的物理化学特性,药物释放特征和生物相容性.
主要方法:
- 采用喷雾干燥技术,制造载有乙醇的奇托桑-帕利戈尔斯基特微粒.
- 物理化学表征包括X射线衍射 (XRD),里埃变换红外光谱 (FTIR),热分析和扫描电子显微镜 (SEM).
- 进行了体外药物释放和生物相容性研究.
主要成果:
- 成功生产了具有高封装效率 (>84%) 的球形微粒.
- 乙胺醇药物在微粒中经历了无形化.
- 开发的微粒体表现出药物释放的延长,其增强的是合石含量.
- 在体外研究证实了微粒的生物相容性.
结论:
- 奇托桑-帕利戈尔斯基特复合物为结核病药物治疗中长期和稳定性乙醇输送提供了一个有前途的系统.
- 该系统有效地降低了ethambutol的高度,并最大限度地减少了与其他联合使用的药物的相互作用.
- 基于成分比的配方优化可以调节药物释放特征.
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