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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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电响应导电混合凝补丁

Jang Ho Ha1, Jae Hyun Lim2, Jong Min Lee3

  • 1Department of Mechanical Engineering, Sogang University, Seoul 04107, Republic of Korea.

Polymers
|June 28, 2023
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种新型的导电混合凝,用于通过皮肤递送药物. 这种电响应的水凝贴片显示可控制的药物释放,增强了智能药物输送系统应用.

关键词:
酸是一种酸.药物释放释放药物释放药物释放的时间电响应混合水凝的混合水凝凝甲基酸盐是什么银色纳米线的纳米线.

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科学领域:

  • 生物材料科学 生物材料科学
  • 材料化学 材料化学
  • 药物输送系统 药物输送系统

背景情况:

  • 水凝是广泛研究的通过皮肤递送药物系统 (TDDS).
  • 之前的研究重点是混合水凝以改善物理/化学性能.
  • 关于提高水凝电导率和药物递送能力的研究有限.

研究的目的:

  • 为TDDS开发一种导电混合水凝,其电气性能得到改善.
  • 研究银纳米线 (AgNW) 和凝甲酸盐 (GelMA) 在提高水凝性能方面的潜力.
  • 为了证明从开发的水凝贴片中释放电响应,开关可控的药物.

主要方法:

  • 通过混合酸盐,GelMA和AgNW来制造混合凝.
  • 混合水凝的抗拉强度和电导率的表征.
  • 在电刺激 (ES) 下评估水凝贴片的药物释放特征.

主要成果:

  • 混合GelMA将水凝的抗拉强度提高了1.8倍.
  • 添加AgNW使电导率提高了18倍.
  • GelMA-alginate-AgNW (Gel-Alg-AgNW) 水凝补丁在ES上显示可控制的多克索鲁比辛释放 (57%).

结论:

  • 开发的电响应混合水凝表现出增强的机械和电气性能.
  • 凝-Alg-AgNW水凝贴片可以通过电刺激精确地控制药物释放.
  • 这种智能水凝贴片对先进的透皮药物递送应用具有重大前景.