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含胰岛素的大豆三素抑制剂-花素纳米颗粒:制备,表征和保护作用评估

Yihao Zhang¹, Ruijia Liu¹, Qixu Feng¹

¹Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, National Soybean Processing Industry Technology Innovation Center, Beijing Technology and Business University, Beijing 100048, China.

|June 28, 2023

概括

大豆素抑制剂-奇托桑纳米颗粒有效封装胰岛素,增强其在胃肠道中的稳定性. 这种新的方法为口服胰岛素的输送提供了一个有前途的策略,提高了治疗潜力.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

口服胰岛素的输送面临着由于胃肠道酶降解的挑战.
开发保护性纳米载体对于改善胰岛素稳定性和生物可用性至关重要.

研究的目的:

使用大豆素抑制剂 (STI) 和奇托 (CS) 制备和描述载有胰岛素的纳米颗粒.
为了评估胰岛素装载纳米颗粒在模拟胃肠道液体中的体外稳定性和释放特征.

主要方法:

通过复杂的化方法制备了载有胰岛素的纳米粒子 (INs-STI-CS).
特性包括颗粒大小,多分散度指数 (PDI) 和封装效率.
在体外研究中,在模拟的胃和肠液 (SGF和SIF) 中评估了胰岛素释放和酶降解.

主要成果:

最佳的纳米颗粒制剂实现了高胰岛素封装效率 (85.07%) ,颗粒大小为350 ± 5nm,PDI为0.13.
在INs-STI-CS纳米颗粒显示显著改善胰岛素稳定性对酶降解.
在模拟的肠液中10小时后,相比于完全消化自由胰岛素,封装胰岛素的27.71%仍然存在.

结论:

载有胰岛素的STI-CS纳米颗粒提供了对胃肠道降解的增强保护.
这些发现为开发稳定的口服胰岛素配方提供了理论基础.
开发的纳米颗粒代表了口服类药物输送的有前途平台.

关键词:

基多酸盐的使用方法复杂的联合化.胰岛素的胰岛素胰岛素是什么纳米颗粒是一种纳米粒子.豆类素抑制剂豆类素抑制剂

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