作为有趣的生物活性产品,有利的异芳香基聚尿素衍生物作为有趣的生物活性产品
Mostafa A Hussien1, Gadeer R Ashour2, Soha M Albukhari1
1Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Polymers
|June 28, 2023
概括
研究人员合成了新的基于 thiazole 的聚尿素聚合物 (PU1-5) 与硫链接. 3显示出显著的抗菌和抗真菌活性,而芳香衍生物显示出较高的结晶性和热稳定性,而非芳香衍生物.
科学领域:
- 材料科学 材料科学 材料科学
- 聚合物化学 聚合物化学
- 有机合成 有机合成
背景情况:
- 新型异芳性聚合物的开发对于先进的材料应用至关重要.
- 基于 thiazole 的聚合物具有独特的电子和结构性质.
- 结合硫链可以影响聚合物的特性和性能.
研究的目的:
- 合成和表征一种新的基于 thiazole 的聚尿素衍生物 (PU1-5) 系列,其主要链中含有硫.
- 研究合成聚合物的结构,热,形态和生物特性.
- 为了评估聚合物的抗微生物活性对选择的细菌和真菌菌株.
主要方法:
- 基于二硫化物的氨基亚醇单体 (M2) 的溶液聚凝与各种二酸盐在pyridine.
- 使用X射线衍射 (XRD),扫描电子显微镜 (SEM) 和热分析 (TGA) 的表征.
- 对 *E. coli*, *S. aureus* 和 *C. albicans* 的模型生物进行抗菌敏感性测试.
主要成果:
- 芳香基聚合物 (PU1,PU2,PU3) 的结晶度高于亚利法基 (PU4) 和循环基 (PU5) 衍生物.
- SEM揭示了不同的表面形态,包括多孔,板状和珊瑚状的结构.
- PU3对测试的细菌和真菌表现出最强的抑制作用;PU4和PU5的抗真菌活性较低.
结论:
- 合成的基于 thiazole 的多尿素具有可调节的结构和形态特性.
- 这些聚合物具有良好的热稳定性和不同程度的抗菌活性.
- 这项研究突显了含硫异芳多尿素在抗微生物应用中的潜力.
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