三剂量mRNACOVID-19疫苗方案在患有固体癌症的患者中产生了适当的免疫性和令人满意的有效性
Urska Janzic1,2, Urska Bidovec-Stojkovic3, Peter Korosec3,4
1Department of Medical Oncology, University Clinic of Respiratory and Allergic Diseases Golnik, 4204 Golnik, Slovenia.
Vaccines
|June 28, 2023
概括
第三剂COVID-19疫苗显著提高了癌症患者的抗体水平,提供了对严重疾病的保护. 这种强制性疫苗接种对于患有固体恶性瘤的人来说是安全有效的.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 癌症患者容易受到严重的COVID-19结果的影响.
- 对这一群体来说,评估COVID-19疫苗接种的影响,包括强剂量,至关重要.
- 以前的研究表明,需要评估免疫功能低下个体的疫苗有效性.
研究的目的:
- 在癌症患者中评估第三次COVID-19疫苗增剂剂的免疫性,有效性和安全性.
- 在接种疫苗后评估抗体水平 (抗SARS-CoV-2 S1 IgG).
- 为了确定疫苗在预防严重SARS-CoV-2感染方面的有效性.
主要方法:
- 一项前性研究跟踪了接受初级疫苗接种和第三剂mRNA强剂的癌症患者.
- 在不同时间点测量了抗SARS-CoV-2 S1 IgG水平.
- 监测SARS-CoV-2感染,疾病严重程度和不良事件的患者.
主要成果:
- 第三次增强剂量导致中位数抗SARS-CoV-2 S1 IgG水平增加20倍,与健康对照相比.
- 抗体水平在3个月和6个月后出现下降.
- 没有患者在接收第三剂补充剂后经历了COVID-19的严重疾病或致命结果.
结论:
- 第三次COVID-19增剂疫苗接种剂在固体癌症患者中具有免疫性.
- 增强剂量是安全和有效的预防严重的COVID-19疾病进展在这个队列.
- 疫苗接种策略应考虑针对癌症患者等免疫受损人群的增强剂量.
更多相关视频
09:15Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
3.5K
15:04Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
12.2K
相关概念视频
Cancer Vaccines
433
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
433
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Cancer Therapies
7.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.8K
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
