儿童脏移植接种者的SARS-CoV-2疫苗接种免疫反应:系统性审查和元分析
Elpida Emmanouilidou-Fotoulaki1, Vasiliki Karava1, John Dotis1
1Pediatric Nephrology Unit, 1st Department of Pediatrics, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
Vaccines
|June 28, 2023
概括
在小儿移植接受者 (KTRs) 中的SARS-CoV-2疫苗接种显示出幽默反应. 建议进行第三剂疫苗接种,因为利图西马布,mycophenolate mofetil和较低的GFR降低了血清转化.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科脏病学 儿科脏病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 儿童移植接受者 (KTRs) 面临更高的SARS-CoV-2风险,因为免疫抑制.
- 了解疫苗在这个脆弱群体中的有效性至关重要.
研究的目的:
- 系统地审查儿童和青少年KTR中SARS-CoV-2疫苗的疗效.
- 为了确定与疫苗接种后缺乏血清转化相关的风险因素.
主要方法:
- 一个系统的审查和PubMed-MEDLINE队列研究的元分析.
- 包括7项研究,包括254个儿科和青少年KTRs.
- 使用固定和随机效应模型进行分析.
主要成果:
- 两剂SARS-CoV-2疫苗接种产生了63%的血清转化率,第三剂后增加到85%.
- 与mycophenolate mofetil和azathioprine (OR 0.09) 相比,观察到较低的血清阳性.
- 利图西马布使用 (OR 0.12) 和较低的GFR与减少血清转化有关.
结论:
- 接种SARS-CoV-2疫苗会在儿科和青少年KTR中引起幽默反应.
- 建议使用第三剂疫苗来增强免疫性.
- 诸如先前的利图西马布,mycophenolate mofetil和降低的GFR等因素会对血清转化概率产生负面影响.
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