一个关于胃潰瘍疾病和COVID-19严重程度之间的关联的元分析
Ying Wang1, Jie Xu1, Liqin Shi1
1Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Vaccines
|June 28, 2023
概括
胃潰瘍疾病整體來說並不顯著增加嚴重冠狀病毒疾病2019 (COVID-19) 的風險. 然而,患有胃潰瘍的老年人 (≥60歲) 面臨更高的嚴重COVID-19結果的風險.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 胃病 (PUD) 和2019年新冠肺炎 (COVID-19) 严重程度之间的关系尚不清楚.
- 个别研究对这种关联产生了不确定的结果.
研究的目的:
- 进行一项元分析,调查胃潰瘍疾病与COVID-19严重程度之间的关联.
- 为了确定PUD是否是更严重的COVID-19结果的风险因素.
主要方法:
- 用15项符合条件的研究的数据进行了全面的元分析.
- 从4,533,426名参与者收集了数据,使用随机效应模型.
- 统计分析包括异质性评估 (I2,Cochran的Q) 和出版偏差评估 (Egger的,Begg的测试).
主要成果:
- 总体而言,PUD和严重COVID-19风险增加之间没有发现显著的关联 (合并OR=1.17,95%CI:0.97-1.41).
- 亚组分析显示,在60岁及以上的患者中,PUD和较高的COVID-19严重性风险之间存在显著的关联 (合并OR=1.15,95%CI:1.01-1.32).
- 在60岁以下的患者中没有观察到显著的相关性 (合并OR=1.16,95%CI:0.89-1.50).
结论:
- 胃潰瘍疾病不是一般人群中嚴重COVID-19的重大風險因素.
- 患有胃潰瘍疾病的老年人 (≥60歲) 呈現嚴重COVID-19的風險增加.
- 年龄是改变PUD和COVID-19严重程度之间的关联的一个关键因素.
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