非洲猪瘟病毒与宿主天生的免疫因子的相互作用
Ayoola Ebenezer Afe1,2, Zhao-Ji Shen2, Xiaorong Guo3
1Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518000, China.
Viruses
|June 28, 2023
概括
非洲猪瘟病毒 (ASFV) 在养猪业造成了毁灭性的损失. 本综述探讨了ASFV如何逃避宿主免疫系统,并讨论了 ASFV 耐药猪的繁殖.
科学领域:
- 兽医病毒学 兽医病毒学
- 免疫学 免疫学 免疫学
- 动物遗传学动物遗传学
背景情况:
- 非洲猪瘟病毒 (ASFV) 对全球养猪业构成严重威胁,其特点是国内猪的高死亡率.
- 像 warthogs 和这样的自然储存库仍然没有症状,复杂化了疾病控制工作.
- 了解ASFV与宿主免疫的相互作用对于开发有效的对策至关重要.
研究的目的:
- 审查ASFV蛋白质与家猪的先天免疫系统之间的复杂相互作用.
- 阐明ASFV用来抑制宿主抗病毒反应的病毒机制.
- 讨论养殖抗ASFV的家猪作为可持续解决方案的可能性.
主要方法:
- 文献综述侧重于ASFV与宿主免疫相互作用.
- 分析病毒蛋白在调节宿主信号通路中的功能.
- 猪中遗传抵抗机制的探索.
主要成果:
- ASFV利用不同的策略来抑制宿主抗病毒免疫力.
- ASFV所准的关键信号通路包括cGAS-STING,NF-κB和TGF-β.
- 病毒蛋白参与操纵无处不在和亡途径以促进感染.
结论:
- 通过复杂的蛋白质机制,ASFV积极破坏先天免疫力.
- 开发抗ASFV的猪品种为消除疾病提供了一个有希望的长期战略.
- 对ASFV与宿主相互作用的进一步研究可以指导开发新的控制措施.
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