系统性硬化症中的口腔开口:来自法国国家队列研究的纵向分析
Benjamin Chaigne1,2, Alexandre Bense1,2, Christian Agard3
1Service de Médecine Interne, Centre de Référence Maladies Autoimmunes Systémiques Rares d'Ile de France, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Ile de France, France.
Journal of internal medicine
|June 28, 2023
概括
在全身性硬化症 (SSc) 中,口腔开口 (MO) 轨迹大多是稳定的,但可以预测疾病的严重程度和生存率. 患有MO降低的分散皮肤SSc患者的一个子组面临着较低生存率和肺部疾病的风险.
科学领域:
- 类风湿病学 类风湿病学
- 临床医学 临床医学
- 系统性自身免疫性疾病
背景情况:
- 有限的研究存在于系统性硬化症 (SSc) 中的口腔开口 (MO).
- 之前没有任何研究研究过SSc患者的MO轨迹.
- 了解MO变化对于评估SSc进展至关重要.
研究的目的:
- 为了研究系统性硬化症 (SSc) 患者的口腔开口 (MO) 轨迹.
- 为了确定MO测量和SSc预后之间的关联.
- 根据MO模式识别患者子组.
主要方法:
- 一项多中心研究,涉及来自法国国家SSc队列的1101名患者.
- 基线MO的评估和个别MO轨迹的建模.
- 隐藏过程混合建模来分析MO模式及其预后价值.
主要成果:
- 基线MO与SSc疾病严重程度相关.
- MO<30毫米与30年生存率降低和肺动脉高血压风险增加有关.
- 潜在过程建模确定了三个MO轨迹组,预测SSc存活率和间歇性肺病 (ILD) 的发生.
- 一个分布式皮肤SSc (dcSSc) 的小组 (9.5%) 呈现出高但下降的MO,表明存活率差和ILD的风险增加.
结论:
- 口腔打开 (MO) 是预测SSc严重程度和生存的简单,可靠的措施.
- 虽然大多数SSc患者的MO是稳定的,但dcSSc患者的MO下降表明不良结果的风险增加.
- MO轨迹分析为SSc管理提供了有价值的预后见解.
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