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与阿斯巴拉金酶相关的胰腺炎的长期影响
Mette Tiedemann Skipper1,2, Birgitte Klug Albertsen1,2, Kjeld Schmiegelow3,4
1Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark.
Pediatric blood & cancer
|June 28, 2023
概括
治疗白血病的阿斯巴拉基纳斯可以导致胰腺炎,这是一个严重的副作用. 本评论概述了潜在的长期健康影响,并为管理这些患者的临床医生提供了后续框架.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 儿科血液学/瘤学
背景情况:
- 阿斯巴拉基纳斯治疗对于急性淋巴细胞白血病 (ALL) 是至关重要的,但经常导致胰腺炎.
- 胰腺炎是与阿斯巴拉基纳斯治疗相关的显著毒性,需要临床关注.
- 目前的指导方针缺乏关于阿斯巴拉金酶相关胰腺炎患者的长期随访的共识.
研究的目的:
- 审查阿斯巴拉金酶相关胰腺炎的潜在长期健康相关影响.
- 为在阿斯巴拉基纳斯治疗期间和之后的患者随访提供临床框架.
- 强调在所有幸存者中监测胰腺炎的后果的重要性.
主要方法:
- 这是一个基于对现有文献和临床经验的审查的评论.
- 作者综合了关于阿斯巴拉基纳斯诱导胰腺炎及其潜在并发症的当前知识.
- 建议制定临床管理和随访的框架.
主要成果:
- 阿斯巴拉金酶相关的胰腺炎可能导致慢性或复发性胰腺炎,胰腺功能不全和糖尿病.
- 长期影响可能包括内分泌和外分泌胰腺功能障碍.
- 长期影响的风险和性质需要结构化的后续协议.
结论:
- 对于那些患有胰腺炎的阿斯巴拉金酶治疗患者来说,标准化的随访方法是必不可少的.
- 早期识别和治疗长期并发症可以改善患者的治疗结果.
- 需要进一步的研究,以建立基于证据的指导方针来管理与阿斯巴拉基纳相关的胰腺炎后续.
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