胸膜切除术的医院间转移期间心脏病核心生长在夜间更快
Pierre Seners1,2,3,4, Michael Mlynash1, Anirudh Sreekrishnan1,4
1Stanford Stroke Center, Stanford University, Palo Alto (P.S., M.M., A.S., M.G.L., G.W.A.).
Stroke
|June 28, 2023
概括
晚上转移的急性缺血性中风患者与白天转移的患者相比,心脏病的增长速度更快. 这一发现表明,对人类中风的进展有潜在的昼夜影响.
科学领域:
- 神经学 神经学
- 脑卒中医学 脑卒中医学
- 循环节生物学 日间生物
背景情况:
- 临床前模型表明,白天缺血期间心脏病发作 (IG) 的增长速度更快.
- 人类研究假设由于逆休息活动周期,夜间IG更快.
研究的目的:
- 调查急性缺血性中风患者的白天和夜间医院间转移之间是否存在心脏病增长率的差异.
- 评估转移时间对中风进展的影响.
主要方法:
- 在225名急性缺血性中风患者的回顾性分析中,大血管封闭在中心之间转移.
- 使用序列扩散加权成像计算医院间心脏病发作增长率.
- 多变量分析根据临床和成像因素进行调整.
主要成果:
- 与白天转移 (1.4 mL/h) 相比,夜间转移 (4.3 mL/h) 的医院间心脏病发作的中位数增长显著更快.
- 夜间转移独立地与较高的心脏病发作增长率有关.
结论:
- 在夜间转移的患者中,医院间心脏病发作的增长速度更快.
- 这些发现对优化急性中风工作流程和神经保护试验设计有意义.
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