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功能化纳米酶与药物加载,用于增强催化疗法和化疗的瘤组合治疗

Qian Song¹, Bin Chi², Haiqing Gao¹

¹Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Function Molecules, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei University, Wuhan 430062, China. lingli@hubu.edu.cn.

Journal of materials chemistry. B

|June 28, 2023

概括

这项研究引入了一种新型纳米酶 (Zr/Ce-MOFs/DOX/MnO2),通过产生基基和耗尽谷氨来增强癌症治疗. 这个平台结合了化疗和催化治疗,改善了瘤抑制.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
材料科学材料科学材料科学

背景情况:

基于纳米酶的癌症疗法面临的局限性是由于质 (GSH) 在瘤微环境中 (TME) 捕获基激素 (̇OH).
开发新的纳米酶对于克服这些局限性和提高治疗疗效至关重要.

研究的目的:

构建一种新的纳米酶 (Zr/Ce-MOFs/DOX/MnO2),用于联合化疗和催化瘤治疗.
通过耗尽GSH来增强OH生成,并使pH/GSH双刺激的多克索鲁比 (DOX) 释放.
用Mn2+作为T1-MRI指导治疗的对比剂.

主要方法:

在Zr/Ce-MOFs/DOX/MnO2纳米酶的合成.
在模拟的TME中评估OH生成.
在双重pH/GSH刺激下评估GSH耗尽和DOX释放.
在体外和体外癌症治疗实验.
使用Mn2+作为对比剂进行T1-MRI成像.

主要成果:

在模拟的TME中,Zr/Ce-MOFs/DOX/MnO2有效地产生了OH和耗尽了GSH.
pH/GSH双刺激导致了加速的DOX释放.
该纳米酶在体外和体外表现出显著的抗瘤作用.
生成的Mn2+离子作为有效的T1-MRI对比剂.

结论:

Zr/Ce-MOFs/DOX/MnO2代表了一个有前途的纳米酶平台,用于增强组合化疗和催化瘤治疗.
双刺激药物释放和MRI导向成像能力为癌症治疗提供了一种多功能方法.
这项工作为克服TME相关挑战在基于纳米酶的癌症治疗中提供了新的战略.

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