编程细胞衍生的囊泡具有增强的免疫调节特性
Khaga R Neupane1, Geraldine S Ramon2, Brock Harvey1
1Department of Chemistry, University of Kentucky, 506 Library Drive, 125 Chemistry-Physics Building, Lexington, KY, 40506, USA.
Advanced healthcare materials
|June 28, 2023
概括
这项研究引入了编程的纳米纤维来重新编程与瘤相关的巨细胞 (TAMs) 从M2状态的前瘤到M1状态的抗瘤,提供了一种新的癌症免疫治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
- 癌症生物学 癌症生物学
背景情况:
- 与瘤相关的巨细胞 (TAMs) 主导着瘤微环境,通常表现出一种亲瘤M2表型.
- 巨细胞极化是可逆的,通过将它们转移到抗瘤M1表型,从而提供治疗潜力.
研究的目的:
- 开发编程纳米纤维作为癌症治疗的免疫调节平台.
- 为了在瘤微环境中重新两极化M2巨细胞,使其转向瘤微环境中的亲炎性M1表型.
主要方法:
- 工程细胞膜衍生的纳米纤维具有特定的免疫调节性质.
- 装饰着带有膜结合的连接体的纳米纤维,用于向免疫细胞的向输送.
- 利用巨细胞衍生的囊泡来增强免疫细胞的重编程.
主要成果:
- 证明了编程的纳米纤维能够重新极化M2巨细胞的能力.
- 展示了双向免疫细胞两极化调节.
- 增强免疫细胞的重编程,使其转向一种促炎性表型.
结论:
- 编程纳米纤维代表了癌症免疫治疗的有前途的治疗平台.
- 向调节巨细胞表型可以逆转前瘤功能.
- 这种方法提供了一种新的策略来增强抗瘤免疫力.
相关概念视频
Cell-mediated Immune Responses
Overview
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.


