结合假定色彩测试,压力敏感粘合剂收集和纸张喷雾质谱测试,用于非法药物检测
Sarah Prunty1, Daniel Carmany2, Elizabeth S Dhummakupt3
1Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA. nmanicke@iupui.edu.
The Analyst
|June 28, 2023
概括
这项研究将简单的色彩测试与纸喷雾质谱 (PS-MS) 结合起来,以快速选非法药物. 综合方法提高了准确性,并为公共安全应用提供可靠的药物残留物检测.
科学领域:
- 法医科学 法医科学 法医科学
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 非法贩运和滥用毒品对公共安全和健康构成重大风险.
- 药物查的传统色彩测试缺乏特异性,导致频繁的错误阳性结果.
- 准确和快速的药物检测方法对于执法和公共卫生倡议至关重要.
研究的目的:
- 开发和验证一种用于非法药物残留物收集和分析的联合方法.
- 为了提高特异性,将纸上色彩测试与纸喷雾质谱 (PS-MS) 集成在一起.
- 用常见的色彩测试和各种非法物质来评估方法的性能.
主要方法:
- 药物残留物被采集使用压力敏感的粘合纸.
- 对收集的残留物进行了纸面色彩测试 (硫酸,西蒙,马奎斯).
- 反应后的分析是使用便携式和长板仪器的纸喷雾质谱法 (PS-MS) 进行的.
主要成果:
- 综合方法在色彩测试检测值 (1.2510μg) 上成功证实了药物残留.
- 纸喷雾MS为大多数药物试剂组合提供了确认,在便携式MS上,海洛因/马奎斯试剂是一个小例外.
- 颜色测试产品保持稳定,允许MS检测药物残留在反应后24小时内.
结论:
- 将色彩测试与纸喷雾质谱相结合,为非法药物分析提供了快速,低成本和有效的方法.
- 这种综合技术提高了与单独色彩测试相比的特异性,减少了假阳性.
- 该方法在现实场景中显示出实际实用性,有助于贩毒和滥用调查.
更多相关视频
10:17High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
9.7K
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
11.6K
相关概念视频
01:21Mass Spectrometry: Complex Analysis
830
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
830
01:15High-Performance Liquid Chromatography: Types of Detectors
629
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
629
01:19Gas Chromatography: Types of Detectors-II
431
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
431