整个大脑输入到前侧运动皮层的主要下降路径
Tonghui Xu1, Zitao Jin2, Mei Yang1
1Department of Laboratory Animal Science, Fudan University, Shanghai, People's Republic of China.
Journal of neurophysiology
|June 28, 2023
概括
前侧运动皮质 (ALM) 具有明显的下降途径,共享共同的大脑输入. 这些输入,主要来自侧皮质和体 (TH),具有不同的强度,影响ALM功能.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑的连接性 大脑的连接性
背景情况:
- 前侧运动皮质 (ALM) 对于运动预测和执行至关重要.
- 来自ALM的不同下降路径具有不同的运动作用.
- 了解这些通路的解剖输入是阐明它们电路功能机制的关键.
研究的目的:
- 系统地绘制和比较全脑输入到ALM的不同的下降路径.
- 调查ALM下降通路的多样性功能的解剖基础.
主要方法:
- 在C57BL/6J小鼠中利用了逆行性突触性狂犬病病毒.
- 生成并分析了ALM神经元投射到 thalamus (TH),长髓 (Med),上层结核 (SC) 和核 (Pons) 的全脑输入地图.
主要成果:
- 确定了来自9个主要大脑区域的59个输入区域,这些区域投射到ALM下降路径.
- 揭示了这些通路中的大致相同的全脑输入模式,主要来自双侧皮质和TH.
- 观察到TH,Med,SC和Pons投射ALM神经元的输入权重不同,尽管有共同的输入来源.
结论:
- 不同的ALM下降路径共享共同的解剖输入,主要是ipsilateral皮层和thalamic.
- 这些共享输入的不同强度为ALM通路的差异性功能提供了解剖基础.
- 这些发现为ALM的精确连接和多样化作用提供了关键的解剖洞察力.
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