超重/肥胖和多药耐药结核病之间的关联
Jesus Peinado1,2, Leonid Lecca1, Judith Jiménez1
11 Socios en Salud Sucursal Perú, Lima, Perú.
Revista peruana de medicina experimental y salud publica
|June 28, 2023
概括
超重和肥胖与患者有先前治疗史的多药耐药结核病没有联系. 这一发现表明,体重可能不会影响结核病患者的耐药性.
科学领域:
- 传染性疾病 传染性疾病
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 仍然是一个重大的全球卫生挑战,多药耐药性 (MDR-TB) 复杂化了治疗结果.
- 超重和肥胖在全球越来越普遍,可能会影响免疫反应和代谢过程,可能会影响传染病的进展.
研究的目的:
- 调查超重/肥胖与接受结核病治疗的患者多药耐药性发展之间的关联.
- 为了在有或没有结核病治疗史的患者中区分这种关联.
主要方法:
- 一项采用结核病队列的二次数据进行的横截面研究.
- 分析包括从基线访问的人类测量和药物敏感性测试数据.
- 研究群体包括新的结核病病例和以前接受过结核病治疗的病例.
主要成果:
- 该研究分析了3734例新的结核病例和766名有结核病治疗史的患者.
- 在有结核病治疗史的患者中,超重/肥胖与多药耐药性没有显著的关联.
- 这种关联的患病率为0.97 (95% CI:0.68-1.38).
结论:
- 超重/肥胖与结核病患者的多药耐药性无关,即使是那些有治疗史的人.
- 免疫和代谢系统之间的复杂相互作用受到体重等动态因素的影响,可能不会直接转化为结核病中药物耐药性模式的改变.
更多相关视频
相关概念视频
Pulmonary Tuberculosis I
286
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
286
Pulmonary Tuberculosis V
214
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
214
Obesity
549
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
549
Pulmonary Tuberculosis IV
175
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
175
Pulmonary Tuberculosis III
381
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
381
Pulmonary Tuberculosis II
281
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
281


