双极性障碍青少年的皮层厚度降低和与来自大脑的神经营养因子的关系
Neslihan İnal1, Berrin Cavusoglu2, Çağatay Ermiş3
1Department of Child and Adolescent Psychiatry, Dokuz Eylul University, Izmir, Turkey.
概括
患有早期双相情感障碍 (BD) 的青少年在几个大脑区域显示皮质厚度 (CT) 降低. 右前带带状回环中的皮层厚度与患有BD的青少年的大脑衍生神经营养因子 (BDNF) 水平相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 皮层厚度 (CT) 和来自大脑的神经营养因子 (BDNF) 是双相情感障碍 (BD) 研究的关键领域.
- 以前的研究主要研究了皮下大脑区域体积和BD中神经营养因子水平之间的关系.
研究的目的:
- 调查青少年皮层厚度 (CT) 与早期出现的双相情感障碍 (BD) 和血清BDNF水平之间的关联.
- 探索BDNF作为早期发病BD中神经元完整性的潜在外围生物标志物.
主要方法:
- 结构性磁共振成像 (MRI) 用于CT测量23名患有早期发病的BD和17名健康对照的euthymic患者.
- 收集血液样本以测量BDNF水平.
- 分析了各种额头部,部和部区域的皮层厚度.
主要成果:
- 患有BD的青少年在多个大脑区域显示出显著较低的CT,包括左中额头环,右侧中心环和双边上额头环,效果大小为中等到大.
- 在患有BD的青少年中,在BDNF水平和右前带带状回形体尾部CT (CPRACG) 之间发现了显著的正相关性 (r=0.49,p=0.023).
结论:
- 对于情绪调节至关重要的区域CPRACG的CT与患有BD的年轻人中的BDNF水平呈正相关.
- 这些发现表明,特定区域的CT,特别是CPRACG,可能作为早期BD的潜在神经成像生物标志物,需要在纵向研究中进一步调查.
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