开发和应用基于证据的定向非循环图来评估金属混合物与心脏代谢结果之间的关联
Emily Riseberg1,2, Rachel D Melamed3, Katherine A James4
1Department of Public Health and Community Medicine, Tufts University, Boston, MA, USA.
Epidemiologic methods
|June 28, 2023
概括
这项研究开发了一种新的定向非循环图 (DAG),用于建模金属混合物和心脏代谢健康. DAG确定了 (As) 和 (Mn) 与禁食葡萄糖水平之间的关联.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 因果模型对于理解金属混合物对心脏代谢健康的影响至关重要.
- 以前,对于这些关系,没有发表的基于证据的因果结构存在.
- 定向非循环图 (DAG) 提供了一个可视化和测试这些复杂关联的框架.
研究的目的:
- 开发和评估基于证据的DAG,用于金属混合物暴露和心脏代谢结果.
- 为了确定因果关系路径和测试条件独立性陈述.
- 确定用于估计金属混合物对心脏代谢健康影响的调整集.
主要方法:
- 为了构建DAG,进行了全面的文献搜索.
- 测试了DAG的条件独立声明,使用圣路易斯谷糖尿病研究 (SLVDS) 数据的回归分析 (n=1795).
- 应用了DAG来确定调整集,然后使用先进的统计模型 (贝叶斯核机器回归,线性混合效应,Cox比例危险) 来分析关联.
主要成果:
- 从42篇文章开发了一个基于证据的DAG,产生了74个可测试的条件独立声明.
- 在这些陈述中,SLVDS数据支持了43%.
- 观察到 (As) 和 (Mn) 暴露与禁食葡萄糖水平之间存在显著的关联.
结论:
- 使用DAG的基于证据的方法被成功开发,测试和应用.
- 这种方法有助于分析环境暴露与健康结果之间的复杂关联.
- 该研究强调了特定的金属结果关系,例如As和Mn与禁食葡萄糖.
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