肝细胞生长因子和左心室结构10年变化:动脉样硬化多民族研究 (MESA)
Richard A Ferraro1, Oluseye Ogunmoroti1, Di Zhao2
1Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
CJC open
|June 28, 2023
概括
较高的肝细胞生长因子 (HGF) 水平与不良的左心室 (LV) 改造有关,特别是增加了质量与体积的比率和在10年内减少了LV终端透析体积.
科学领域:
- 心脏病学 心脏病学
- 生物医学研究的研究.
- 分子生物学分子生物学
背景情况:
- 肝细胞生长因子 (HGF) 是一种细胞因子,与心力衰竭 (HF) 有关,特别是心力衰竭与保留射出分数 (HFpEF) 有关.
- 左心室 (LV) 质量和同心重塑,以质量与体积 (M: V) 的比率表示,是HFpEF的可识别成像风险标志物.
研究的目的:
- 调查HGF水平与不利的LV重塑之间的关联.
- 为了确定HGF是否是随着时间的推移LV结构变化的预测因素.
主要方法:
- 从多民族动脉样硬化研究 (MESA) 队列中分析了4907名参与者,在基线时没有心血管疾病.
- 心脏磁共振成像 (CMR) 用于在基线和10年后评估LV结构.
- 采用多变量调整的线性混合效应模型来检查HGF与LV参数的横截面和纵向关联.
主要成果:
- 较高的HGF水平与增加的M:V比率和减少的LV终端透析体积交叉相关.
- 纵向分析显示,在10年内,最高的HGF三位数与M:V比率的显著增加和LV终端透气体积的减少有关.
- 这些关联在调整心血管风险因素和N-终端亲B型尿素后仍然显著.
结论:
- 升高的HGF水平独立地与一个由增加M:V比率和降低LV终端透缩体积的特征特征的同心LV重塑模式相关.
- 这些发现表明,HGF可能代表与HFpEF风险相关的中间表型.
- 这项研究强调了HGF在不良心脏重塑的病理生理学中的潜在作用.
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