对青少年和年轻人的COVID-19疫苗报告的严重不良事件的比较分析
Beniamino Cappelletti-Montano1, Giuseppe Demuru1, Ezio Laconi2
1Department of Mathematics and Computer Sciences, University of Cagliari, Cagliari, Italy.
Frontiers in public health
|June 28, 2023
概括
在青少年和年轻人中,严重不良事件 (SAE) 与流感和HPV疫苗相比,对于COVID-19疫苗显着更高. 男性青少年的风险较高,因此需要对COVID-19疫苗接种活动进行进一步的安全性和危害益处分析.
科学领域:
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在年轻人群体中,COVID-19疫苗的安全性需要彻底调查.
- 与其他常规疫苗接种相对比较的安全数据对于知情的公共卫生战略至关重要.
研究的目的:
- 评估和比较COVID-19疫苗 (mRNA和病毒载体) 对青少年和年轻人的流感和HPV疫苗的安全性.
- 分析美国疫疫苗接种早期安全数据.
主要方法:
- 利用疫苗不良事件报告系统 (VAERS) 对严重不良事件 (SAE) 的数据.
- 分析了包括死亡,危及生命的疾病,残疾和住院住院的SAE.
- 专注于12-17岁和18-49岁的年龄组,每个疫苗类型都有特定的时间框架.
主要成果:
- 青少年报告COVID-19疫苗的SAE率较高 (60.73 / 百万) 与流感 (2.96 / 百万) 和HPV (14.62 / 百万) 相比.
- 年轻成年人对COVID-19疫苗的SAE率较高 (101.91 / 百万) 与流感 (5.35 / 百万) 和 (11.14 / 百万).
- 在COVID-19疫苗中,SAE的发生率明显高:比SAE的发生率高19.60倍. 流感,4.15倍与HPV相比,7.89倍与麻疹相比. 男性青少年的相对风险增加.
结论:
- 与流感和HPV疫苗相比,COVID-19疫苗接种与青少年和年轻成年人中SAE的明显较高率有关.
- 早期的疫苗数据表明,SAE的发病率低于COVID-19疫苗.
- 进一步的研究是必要的,以了解这些差异,并进行准确的危害-益处分析,特别是男性青少年,以指导疫苗政策.
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