脑内支气管光学连贯性断层扫描或计算机断层扫描用于评估支气管切除症的进展
Lin-Ling Cheng1,2, Wei-Jie Guan1,3,2, Chang-Hao Zhong1
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
胸膜内膜的光学连贯性断层扫描 (EB-OCT) 可以识别厚厚的支气管壁,表明支气管切除症的进展. 这一发现,与较高的中性粒细胞弹性酶活性一起,预测了疾病的进展.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 支气管切开症进展的早期放射性迹象尚未得到充分了解.
- 胸部计算机断层扫描 (CT) 和内支气管光学连贯性断层扫描 (EB-OCT) 用于评估支气管切除症.
- 基于厚壁支气管 (TW+) 与周围扩张支气管的缺失 (TW-) 的患者分层是关键.
研究的目的:
- 为了比较EB-OCT和CT,以评估支气管病变的放射性进展.
- 为了确定支气管切除症进展的危险因素.
- 根据CT检测结果对支气管切除症患者进行分层.
主要方法:
- 这是一项前性队列研究,涉及75名患者.
- 胸部CT和EB-OCT在基线和5年随访时进行.
- 评估气道口径指标,细菌微生物学,唾液MMP-9和中性粒细胞弹性酶活性.
主要成果:
- 在基线时,TW+组的EB-OCT指标显著更高.
- 5年后,53.1%的TW+组通过EB-OCT呈现支气管切除症进展,而TW-组为3.3%.
- 在CT上更高的基线中性粒细胞弹性酶活性和TW+支气管预测了进展.
结论:
- 经由EB-OCT识别的扩张支气管周围厚厚的支气管壁,表明支气管切除症的进展.
- EB-OCT是评估支气管切除症进展的一个有价值的工具.
- 中性粒细胞弹性酶活性是支气管切除症进展的预测因素.
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