铁介导的氧化应激通过激活肺腺癌中的c-Myc来诱导PD-L1的表达

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Updated: Jul 25, 2025

Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
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Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression

Published on: January 19, 2019

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Anna Martina Battaglia1, Alessandro Sacco1, Ilenia Aversa2

  • 1Laboratory of Biochemistry and Cellular Biology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy.

Frontiers in cell and developmental biology
|June 28, 2023
PubMed
概括

瘤微环境 (TME) 中的铁丰富性可以促进肺腺癌 (LUAD) 中的编程细胞死亡蛋白1联体1 (PD-L1) 表达. 这种由铁驱动的PD-L1上调抑制T细胞活性,影响免疫治疗的有效性.

关键词:
在PD-L1中.在TME中,它是最重要的.c-Myccc 的意思是我的铁是铁的,铁是铁的肺部腺癌的癌症.氧化应激是一种氧化应激.

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