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Updated: Jul 25, 2025

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells
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基于量子的建模表明,双酸89基质结合增强了氨酸/氨酸蛋白酸酶-2A (PPP2R5D/PPP2R1A/PPP2CA) 介导的脱化

E Alan Salter1, Andrzej Wierzbicki1, Richard E Honkanen2

  • 1Department of Chemistry, University of South Alabama, Mobile, AL, United States.

Frontiers in cell and developmental biology
|June 28, 2023
PubMed
概括

氨酸-89与基质的双酸结合对于最佳的蛋白质酸酶2A (PP2A) 催化功能至关重要. 计算显示,当Arg89直接与基质结合时,激活能量较低,这表明它在调节PP2A活动中的作用.

关键词:
在ONIOM计算中使用ONIOM计算.在PP2A中,PP2A是PP2A.这就是PPP2R5D.酶催化酶的催化作用酸的水解是酸的水解.蛋白质脱化脱化过渡状态的过渡状态.

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