在不同年龄段的喘儿童中,用室内灰尘虫降低的语言下免疫疗法的有效性
Tao Ai1, Peilin Zhang1, Ronghua Luo1
1Pediatric Respiratory Medicine Department, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Frontiers in pediatrics
|June 28, 2023
概括
语言下免疫疗法可以改善儿童的喘控制和肺功能. 这种治疗对所有年龄组都有好处,年幼的儿童表现出更好的小气道阻力改善,年长的儿童经历了加强的喘管理.
科学领域:
- 儿科过敏和免疫学
- 呼吸系统医学 呼吸系统医学
- 免疫治疗是一种免疫疗法.
背景情况:
- 儿童呼吸道过敏,包括喘和鼻炎,越来越普遍.
- 特定免疫疗法 (SIT) 在改善儿科喘患者治疗结果方面表现有前途.
- 有限的研究存在于SIT在儿童过敏喘不同年龄组的有效性.
研究的目的:
- 为了评估子语言免疫疗法 (SLIT) 在儿科过敏性喘患者的有效性.
- 基于年龄组 (6岁以下和6-16岁) 的治疗结果进行比较.
- 评估喘控制,肺功能和呼出的氧化 (FeNO) 的变化.
主要方法:
- 共有200名儿科喘患者接受了常规治疗;100人接受了额外的SLIT (观察组),100人没有 (对照组).
- 患者被分为两个年龄组:6岁以下和6-16岁.
- 测量结果包括FeNO水平,肺功能测试,喘控制测试 (ACT) 评分,药物评分和症状评分.
主要成果:
- 在治疗前,在6岁以下的儿童中,没有观察到小组之间的显著差异.
- 在6至16岁的儿童中,与对照组相比,观察组的基线FVC,FEV1和FEF25显著较低.
- 治疗后,观察组在FEF75,FEF50,FEF25,MMEF75/MMEF25,ACT分数和FeNO水平上与对照组相比显著改善,治疗后年龄组之间没有显著差异.
结论:
- 语言下免疫疗法为所有年龄段的喘儿童提供了显著的好处.
- 年龄较小的儿童 (<6岁) 倾向于改善小气道阻力.
- 学校年龄 (6-16岁) 的儿童在小呼吸道抵抗,喘控制和减少炎症方面经历了显著的改善.
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