当词语第一次失败时:预测由早期疾病中无法分类的异常表现产生的初级渐进性失言症变体的出现
Melissa D Stockbridge1, Donna C Tippett1,2,3, Bonnie L Breining1
1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Aphasiology
|June 28, 2023
概括
早期的认知语言评估可以预测初级渐进性失言症 (PPA) 变体. 特定命名测试得分准确识别了语义或非流利/语法PPA,有助于早期诊断.
科学领域:
- 神经科学是一个神经科学.
- 语言学的语言学.
- 心理学 心理学 心理学
背景情况:
- 初级渐进性失言症 (PPA) 呈现出三个主要变体:语义,非流利/语法,和logopenic.
- 相当多的PPA患者不完全符合这些既定类别,这给诊断带来了挑战.
研究的目的:
- 确定哪些认知语言评估可以预测患者最初呈现为不可分类的PPA的最终变异分类.
- 确定早期诊断标记物,以区分PPA亚型.
主要方法:
- 评估了256名患有PPA的个体,重点关注了19个最初无法分类的病例,后来满足了变种标准.
- 采用接收器操作特征 (ROC) 曲线来评估各种任务的预测能力,用于变种分类.
- 在高面积下曲线任务中使用回归分析来改进预测准确度.
主要成果:
- 对于名词和动词的几个命名评估表明了高的预测价值.
- 波士顿命名测试 (BNT) 单独产生了一个具有高分类准确度的显著预测模型.
- 非常低的BNT得分预测了语义变体,而正常的BNT得分预测了非流利/语法变体.
结论:
- 命名能力,特别是由BNT评估,对于早期PPA变体预测至关重要.
- 不同的BNT性能水平可以区分语义和非流利/语法PPA.
- 在图像-动词验证任务上的高性能有助于识别未来的logopenic PPA (lvPPA).
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