喘对大脑的影响:从扩散MRI,CSF生物标志物和认知衰退中得到的证据
Ajay Kumar Nair1, Carol A Van Hulle2,3, Barbara B Bendlin2,3,4
1Center for Healthy Minds, University of Wisconsin-Madison, Madison, WI 53703, USA.
Brain communications
|June 28, 2023
概括
喘可能通过影响白色和灰色物质微观结构来加速大脑衰老和认知衰退. 有效的喘管理可能会防止认知症状和缓慢神经退行.
科学领域:
- 神经科学是一个神经科学.
- 炎症性疾病 炎症性疾病
- 衰老的衰老 衰老的衰老
背景情况:
- 慢性系统性炎症与神经退行有关,但潜在的机制是复杂的,并受到多种相互作用的风险因素的影响.
- 识别和解决可改变的风险因素,如喘,对于理解和减轻神经退行过程至关重要.
研究的目的:
- 调查喘 (一种慢性炎症性疾病) 对大脑健康的影响,包括白色和灰色物质微观结构,阿尔茨海默氏症病理学和认知功能.
- 为了检查喘是否缓和神经成像和生物标志物数据与认知衰退之间的关系,控制年龄,性别,遗传和心血管风险.
主要方法:
- 一个病例控制研究设计被用于来自威斯康星州阿尔茨海默病研究中心的参与者,包括31名喘患者和186名对照.
- 用多扩散权重成像和三分部神经元定向分散和密度成像模型来评估大脑微观结构.
- 对阿尔茨海默病病理学,质激活,神经炎症和神经退行症的脑脊髓液 (CSF) 生物标志物进行了分析,以及随着时间的推移的认知变化.
主要成果:
- 与对照组相比,喘患者显示出与不良白质指标相关的阿尔茨海默病病理学和突触退行生物标志物较大.
- 衰老对白质完整性的不良影响在喘患者中加快.
- 喘患者白色和灰色物质微观结构的恶化与加速的认知衰退有关.
结论:
- 喘似乎加快了与年龄相关的微观结构性大脑变化和神经病理学,导致更快的认知衰退.
- 有效控制喘可能提供神经保护性益处,可能减缓认知症状和神经退行症的进展.
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