血管对指尖微循环的反应是通过具有不同幅度的局部振动
Lizhong Mu1,2, Aoran Sun1, Youqiang Chen1
1Key Laboratory of Marine Energy Utilization and Energy Conservation, School of Energy and Power, Dalian University of Technology, Dalian, China.
Frontiers in bioengineering and biotechnology
|June 28, 2023
概括
当地振动强度显著影响手指微循环. 增加的振动幅度减少了指尖的血液流动,并提高了炎症标志物,影响了血管内皮细胞调节.
科学领域:
- 生物医学工程 生物医学工程
- 职业健康 职业健康 职业健康
- 生理学 生理学 生理学
背景情况:
- 手传递的振动在职业环境中很常见.
- 暴露于振动可能会影响周围循环和组织健康.
- 了解微循环对振动的反应对于预防职业伤害至关重要.
研究的目的:
- 为了研究当地的振动强度对手指微循环的影响.
- 分析血液 perfusion 和调节机制的变化.
- 评估振动对血管内皮细胞和炎症的影响.
主要方法:
- 在手指尖上用激光多普勒流量计 (LDF) 进行手传输振动实验.
- 波形分析用于研究内皮质,神经和肌源性调节范围.
- 血管内皮细胞 (ECs) 暴露于振动和炎症因子检测的体外研究.
主要成果:
- 低频振动降低了指尖血流,在更高的振幅下更大程度上降低了.
- 血流恢复时间随着振动振幅的增加而增加.
- 振动暴露在EC中增加了核因子-κB (NF-κB) 表达,表明炎症.
结论:
- 高振幅振动诱导血管内皮细胞的炎症.
- 变化的内皮细胞调节活性与振动诱导的炎症有关.
- 内皮功能对于在振动压力下维持微循环血液输液至关重要.
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