在双相高风险背景下,家庭环境和多基因风险
Emma K Stapp1,2, Janice M Fullerton3,4, Rashelle J Musci1
1Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.
JCPP advances
|June 28, 2023
概括
家庭环境显著影响后代患双相情感障碍 (BD) 的风险. 高冲突的家庭环境可能会改变多基因风险评分 (PRS) 对BD责任的影响.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 发展心理学 发展心理学
背景情况:
- 多基因风险 (PRS) 和双相情感障碍 (BD) 发展中的环境因素之间的相互作用尚未得到充分研究.
- 后代对其家庭环境 (FE) 与BD风险相关的看法也不是很清楚.
研究的目的:
- 调查后代感知家庭环境 (FE) 和BD多基因风险评分 (PRS) 之间的相互作用,以确定BD发育的责任.
- 为了检查这些协会的后代与BD的高或低家族风险.
主要方法:
- 招募父母患有BD (高风险) 和没有精神疾病 (低风险) 的后代.
- 基于感知到的凝聚力,灵活性和冲突来分类家庭环境.
- 从全基因组关联研究中计算后代BD-PRS,并使用标准化采访诊断BD.
主要成果:
- 在具有良好运作的家庭环境的后代中观察到BD-PRS和BD责任之间的积极关联.
- 相比之下,在高冲突家庭环境的后代中发现了负相关性,其中较低的BD-PRS与较高的BD风险相关.
- 探索性分析表明,在特定FE和BD-PRS亚组中,自杀念头和自杀企图的比例更高.
结论:
- 根据所感知的家庭环境,BD-PRS和BD责任之间的关系有所不同.
- 这些发现支持BD的多因素责任门模型.
- 强调家庭动态在 BD 发展中的重要性,并建议潜在的干预目标.
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