自闭症谱系障碍中的巴斯皮龙:系统性审查
Nihit Gupta1, Mayank Gupta2, Raghu Gandhi3
1Psychiatry, Dayton Children's Hospital, Dayton, USA.
Cureus
|June 28, 2023
概括
这次审查发现巴斯皮龙在自闭症谱系障碍 (ASD) 中的证据质量不佳. 虽然通常是安全的,但需要更多的研究来确认它对儿童ASD核心症状和同时出现的焦虑的有效性.
科学领域:
- 神经发育障碍 神经发育障碍
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 自闭症谱系障碍 (ASD) 提出了复杂的挑战,通常伴随着焦虑和行为问题.
- 有限的批准药理干预措施存在于核心ASD症状和相关并发症.
- 作为一种焦虑缓解剂的巴斯皮龙已在患有自闭症的儿童群体中探索其潜在的益处.
研究的目的:
- 系统地审查关于巴斯皮龙在治疗ASD核心症状中的有效性和安全性的现有证据.
- 评估巴斯皮龙对ASD儿科患者同时出现的焦虑,易怒和多动性的影响.
- 评估关于在ASD中使用巴斯皮龙的证据的整体质量.
主要方法:
- 对相关临床试验进行主要医学文献数据库的系统搜索.
- 纳入标准侧重于小儿 (<18岁) 用buspirone治疗的ASD患者.
- 包括随机对照试验 (RCT),开放试验,交叉研究和回顾性图表审查.
主要成果:
- 包括6项研究 (2项RCT,2项开放标签,1项交叉研究,1项图表审查).
- 由于RCT的异质性,元分析是不可行的.
- 大多数研究表明,巴斯皮龙在小儿ASD患者中耐受性良好且安全,有些人报告了整体症状的改善.
结论:
- 目前的证据质量很低,需要进行更强大的研究.
- 没有足够的证据来推巴斯皮龙治疗儿童中ASD核心症状,焦虑,易怒或过度活跃.
- 布斯皮龙可以作为一种安全的,非标签的选择,用于ASD中的焦虑,因为它具有良好的安全性.
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