对岛内皮质第5层的剖析揭示了两个分层,它们在食欲饮酒行为中具有对立的调节作用
Makoto Takemoto1, Shigeki Kato2, Kazuto Kobayashi2
1Department of Sensory and Cognitive Physiology, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
iScience
|June 28, 2023
概括
岛内皮质 (岛屿) 5 层有两种神经元类型. 一个抑制水的摄入,而另一个促进它,揭示了双向的作用在胃口的动机.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
背景情况:
- 岛内皮质 (insula) 调节饮食和饮酒行为.
- 之前的研究表明,岛内皮层的投射和功能的前后差异.
- 然而,它的皮层层中的异质性,特别是第5层,仍然不清楚.
研究的目的:
- 为了研究小鼠异粒体岛中的第5层神经元的解剖学和功能异质性.
- 识别5层内不同的神经元亚群及其投射目标.
- 确定这些子群体在动机行为,特别是饮水摄入中的作用.
主要方法:
- 利用免疫组织化学来识别基于标记表达的神经元子群 (NECAB1,CTIP2).
- 采用光遗传学在体内选择性激活不同的神经元群体 (L5a和L5b).
- 评估了光遗传激活对口水口行为对口渴小鼠的影响.
主要成果:
- 鉴定了两种不同的5层神经元子群在异粒状岛屿:L5a (NECAB1+) 和L5b (CTIP2+).
- L5a神经元双向向中枢桃体 (侧面和囊部分) 投射.
- L5b神经元以ipsilateral的方式投射到副亚体细胞核和中央杏仁体 (中间分裂).
- 对L5a神经元的光遗传激活抑制了水,而L5a激活则促进了水.
- 行为变化发生而没有改变喷口偏好或避免.
结论:
- 岛内皮层的第5层含有独特的神经元子群,具有特定的投射模式.
- 这些子群体对水摄入行为产生相反的调节效应.
- 研究结果表明,胰岛层5在食欲行为动机方面的作用是分层特异的,双向的.
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