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Updated: Jul 25, 2025

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

专家MTB/RIF超测试使用便:一种有效的解决方案,用于识别成年肺结核病嫌疑人的细菌,而没有吐的液

Xia Yu¹, Fen Wang¹, Ruyan Ren¹

¹National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, Beijing, China.

Microbiology spectrum

|June 28, 2023

概括

在便样本上的Xpert MTB/RIF Ultra (Xpert-Ultra) 测定显示了对成年人肺结核 (PTB) 诊断的高灵敏度. 这种方法对于无法产生的患者来说是一个有前途的工具,可以改善PTB检测.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
诊断诊断诊断诊断

背景情况:

肺结核 (PTB) 诊断在很大程度上依赖于呼吸道样本,这给无法吐的患者带来了挑战.
在PTB诊断中,Xpert MTB/RIF Ultra (Xpert-Ultra) 试验提供了替代样本类型的潜力.

研究的目的:

为了评估基于便的Xpert-Ultra测试对成人肺结核的诊断性能.
为了比较基于便的Xpert-Ultra与呼吸道样本 (RTS) 和基于便的Xpert MTB/RIF (Xpert) 测试.

主要方法:

一项前性研究招募了130名可能患有PTB的患者.
呼吸道样本和便样本使用涂抹显微镜,MGIT960液体培养,Xpert和Xpert-Ultra进行了测试.
通过比较测试结果与确认的PTB病例来评估诊断性能.

主要成果:

基于便的Xpert-Ultra显示了79.45%的灵敏度,明显高于涂抹 (10.96%),培养 (23.28%) 和基于便的Xpert (60.27%).
在RTS和便中,Xpert和Xpert-Ultra的特异性为100%.
所有五个经过支气管支气管洗液 (BALF) 确认的PTB病例均在便Xpert-Ultra.中呈阳性.

结论:

基于便的Xpert-Ultra测定是一种有价值和实用的策略,可以改善PTB诊断,特别是在无法吐的患者中.
便Xpert-Ultra的灵敏度与呼吸道样本上的Xpert相似.
在成年人中使用便Xpert-Ultra进行"追踪电话"强烈支持PTB诊断.

关键词:

在MTB Xpert/RIF Ultra中使用.在Xpert MTB/RIF中使用.肺结核 - 肺结核便是一个便.

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