在肥胖和NAFLD中认知障碍的患病率和危险因素
Charlotte W Wernberg1,2, Lea L Grønkjær1, Birgitte Gade Jacobsen1
1Department of Gastroenterology and Hepatology, Liver Research Group, University Hospital of Southern Denmark, Esbjerg, Denmark.
Hepatology communications
|June 28, 2023
概括
几乎一半的严重肥胖患者表现出认知障碍,独立于非酒精性脂肪肝 (NAFLD) 或其他肥胖并发症. 这突显了严重肥胖症的显著认知负担.
科学领域:
- 代谢和腹部手术 代谢和腹部手术
- 神经心理学 神经心理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 严重的肥胖与认知功能障碍和非酒精性脂肪性肝病 (NAFLD) 有关,但它们之间的关联尚未完全理解.
- 研究严重肥胖个体的认知功能对于了解与肥胖相关的健康影响至关重要.
研究的目的:
- 为了确定严重肥胖的患者认知功能障碍的患病率和特征,接受减肥手术评估.
- 检查认知功能障碍与NAFLD的存在/严重程度,与肥胖相关的并发症和神经元损伤标志物的关系.
主要方法:
- 一项涉及180名严重肥胖患者 (BMI ≥35 kg/m2) 的横截面研究,这些患者被评估为减肥手术.
- 认知功能使用基本测试 (连续反应时间,移植系统性脑病综合征,Stroop) 和神经心理状态评估可重复电池 (RBANS) 进行评估.
- 肝脏活检用于NAFLD评估,并将Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) 作为神经元损伤生物标志物.
主要成果:
- 41%的患者表现出基于RBANS的认知障碍,执行功能和短期记忆最受影响.
- 认知障碍与BMI,NAFLD存在/严重程度或代谢并发症之间没有发现显著的关联.
- 男性性别和多种精神活性药物的使用与认知障碍有关;TREM2没有显示任何关联.
结论:
- 严重肥胖患者中很大一部分患有多领域认知障碍.
- 在这个队列中,认知障碍与非酒精性脂肪性肝病或其他常见的与肥胖相关的并发症无关.
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