已治愈的HCV患者的乙型肝炎疫苗反应低于最佳,表现出高的自我反应性免疫特征
Ming-Ju Zhou1,2, Chao Zhang2, Yuan-Jie Fu2
1Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Hepatology communications
|June 28, 2023
概括
治愈的型肝炎病毒 (HCV) 患者表现出持久的免疫变化. 高水平的自我反应性免疫细胞与这些人对乙型肝炎疫苗接种反应较弱有关.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 慢性型肝炎病毒 (HCV) 感染导致持续的免疫系统变化,即使在病毒清除后.
- 这些免疫变化对HCV治愈个体的疫苗反应的影响尚不清楚.
研究的目的:
- 为了研究HCV治愈的患者免疫细胞子集的变化.
- 为了确定特定的免疫特征是否与治愈的HCV患者的乙型肝炎疫苗反应相关.
主要方法:
- 使用光谱流细胞计,对T细胞和B细胞子集进行高维免疫类型定型.
- 与健康对照组相比,分析了13名用乙型肝炎疫苗接种的HCV治愈患者.
- 根据抗体水平,将患者分为高响应者 (HR) 和非响应者 (NR1).
主要成果:
- 与健康对照组相比,在治愈的HCV患者中,39.5%的免疫细胞子集发生了变化.
- 免疫细胞的变化在非响应者中更为明显 (NR1).
- 高水平的自我反应性免疫特征 (Tregs,TD/CD8,仅IgD的B记忆,自身抗体) 与不理想的乙型肝炎疫苗反应有关.
结论:
- 治愈的HCV患者表现出持续的适应性免疫系统干扰.
- 高度自我反应的免疫特征可能会损害先前感染HCV的个体的乙型肝炎疫苗的疗效.
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