脂肪肝疾病的实验模型:状态和评估
Hua Wang1,2, Haiyuan Shen1,2, Wonhyo Seo3
1Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Hepatology communications
|June 28, 2023
概括
脂肪肝疾病,如与酒精有关的肝病 (ALD) 和非酒精性脂肪肝病 (NAFLD),缺乏有效的治疗方法. 本综述审查了当前用于ALD和NAFLD研究的临床前模型,强调了它们的局限性.
科学领域:
- 肝病学和转化医学.
- 专注于肝病研究和治疗开发.
背景情况:
- 酒精相关性肝病 (ALD) 和非酒精性脂肪性肝病 (NAFLD) 是导致末期肝病的主要原因,包括肝硬化和肝细胞癌 (HCC).
- 目前,对于ALD或NAFLD没有经批准的药理疗法,这凸显了对新型治疗策略的急需.
- 临床治疗发展的一个重大障碍是缺乏充分验证的临床前疾病模型,这些模型完全代表了ALD和NAFLD的谱.
结论:
- 改进和更全面的临床前模型对于推动发现有效的ALD和NAFLD治疗方法至关重要.
- 对模型开发的进一步研究对于克服当前的治疗局至关重要.
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