睡眠障碍是否与胃肠道癌症的风险有关? - - 一项病例对照研究
Sven Loosen1, Sarah Krieg1, Andreas Krieg2
1Department of Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty of Heinrich Heine University Duesseldorf, University Hospital Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany.
Journal of cancer research and clinical oncology
|June 28, 2023
概括
睡眠障碍,特别是在诊断前一年内,与胃肠道癌症有关. 查睡眠障碍可能有助于癌症预防策略.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠障碍在全球普遍存在,与许多健康问题有关.
- 新出现的证据将睡眠障碍与癌症风险增加联系在一起.
- 睡眠障碍与胃肠癌之间的关系需要进一步研究.
研究的目的:
- 调查睡眠障碍与患胃肠道癌症的风险之间的联系.
- 为了确定睡眠障碍在患有肠胃癌的患者中是否比没有肠胃癌的患者更常见.
主要方法:
- 对被诊断患有肠胃癌的成年患者的回顾性分析与匹配的对照队列相比.
- 利用DA数据库 (IQVIA) 来获取2010年1月至2022年12月的患者数据.
- 采用后勤回归模型来计算关联的赔率比率 (OR) 和95%置信区间 (95%CI).
主要成果:
- 分析包括37161例胃肠道癌症病例和37161例对照病例.
- 在长期病史中,没有发现睡眠障碍与整体相关性 (OR 1.04).
- 在诊断前一年内记录的睡眠障碍与肠道癌有积极的关联 (OR 1.20).
- 在胃癌,胰腺癌和结肠直肠癌诊断之前,观察到睡眠障碍的几率更高.
结论:
- 睡眠障碍可能是短期健康结果的早期指标,包括肠道癌症.
- 睡眠障碍查可能是癌症预防计划的宝贵组成部分.
- 研究结果强调了睡眠健康在胃肠道癌症风险评估中的潜在作用.
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