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在青少年ADHD病例控制研究中,ADHD,与任务相关的行为措施和响应抑制期间的大脑激活之间的共同遗传病因

Gülhan Saraçaydın^1,2, I Hyun Ruisch^3,4, Daan van Rooij⁵

¹Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. g.saracaydin@accare.nl.

European archives of psychiatry and clinical neuroscience

|June 28, 2023

概括

注意缺陷/多动障碍 (ADHD) 的遗传风险与反应抑制较差有关,影响行为和大脑活动. 这表明ADHD及其相关的抑制挑战具有共同的遗传基础.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
遗传学是一个遗传学.

背景情况:

响应抑制障碍是注意力缺陷/多动障碍 (ADHD) 的关键特征,可能代表一种内分类型.
了解抑制反应的遗传基础对于ADHD研究至关重要.

研究的目的:

研究ADHD (PRS-ADHD) 的多基因风险评分与反应抑制的行为和神经相关物之间的关系.
探索潜在的调解途径,将遗传责任与ADHD症状联系起来.

主要方法:

功能磁共振成像 (fMRI) 和行为数据是在454名参与者 (ADHD病例,未受影响的兄弟姐妹,对照) 的停止信号任务中收集的.
全基因组基因型化被用来构建PRS-ADHD.
使用康纳斯家长评分表来评估ADHD症状的严重程度.

主要成果:

PRS-ADHD与ADHD症状严重程度,反应时间更慢/更可变,以及在响应抑制期间改变前-状网络激活有关.
反应时间及其可变性介导了PRS-ADHD和ADHD症状之间的联系.
在失败的抑制过程中,左极和前额准海马环中的大脑活动调解了PRS-ADHD-多动性/冲动性关系.

结论:

患ADHD的多基因风险与症状严重程度的范围内的反应抑制的行为和神经方面有关.
研究结果表明,ADHD和响应抑制缺陷之间存在共同的遗传病因.
通过反应抑制,表明从遗传责任到ADHD到过度活跃/冲动性的潜在机制性途径.

关键词:

注意力缺陷/多动症障碍注意力缺陷/多动症多基因风险评分多基因风险评分.响应抑制反应的抑制.停止信号任务任务停止信号任务功能磁力共振成像 (fMRI) 是一种

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