与COVID-19感染相关的线粒体功能障碍的潜在生物标志物
Nadia Turton1, Lauren Millichap2, Iain P Hargreaves3
1School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.
Advances in experimental medicine and biology
|June 28, 2023
概括
线粒体功能障碍可能会影响COVID-19和长期COVID的结果,特别是在那些具有先前存在的线粒体呼吸链 (MRC) 障碍的人中. 诊断包括分析代谢物,像FGF-21这样的细胞因子和氧化应激标记物,MRC酶活性是最可靠的指标.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 代谢学 代谢学 代谢学
背景情况:
- 线粒体是免疫反应的关键调节者,病毒感染可以改变线粒体功能.
- COVID-19和长期COVID的临床结果可能与线粒体功能障碍有关.
- 患有线粒体呼吸链 (MRC) 疾病的个人可能面临更严重的COVID-19和长期COVID.
研究的目的:
- 探索线粒体功能障碍与COVID-19/长期COVID之间的联系.
- 为了确定潜在的生物标志物来诊断COVID-19患者的线粒体功能障碍.
- 评估各种诊断方法对线粒体功能障碍的有用性.
主要方法:
- 血液和尿路代谢物 (乳酸,有机酸,氨基酸) 的分析.
- 测量类似激素的细胞因子,如纤维细胞生长因子-21 (FGF-21).
- 评估氧化应激参数 (GSH,辅酶Q10).
- 用光谱测量测定组织中的MRC酶活性.
- 应用多重目标代谢分析.
主要成果:
- 线粒体功能障碍与COVID-19和长期COVID有关.
- 一系列生物标志物,包括代谢物,FGF-21和氧化应激标志物,可以表明MRC功能障碍.
- 在组织中直接测量MRC酶活性仍然是诊断MRC功能障碍的黄金标准.
- 多重化分析提高了线粒体功能障碍的诊断准确度.
结论:
- 线粒体功能障碍是COVID-19和长期COVID的重要因素.
- 生物标志物的组合,包括像FGF-21这样的新型生物标志物,有助于诊断.
- 综合诊断策略,特别是多重代谢分析,对于准确评估COVID-19后患者的线粒体功能障碍至关重要.
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