类药物:对治疗COVID-19的有益影响
Naser-Aldin Lashgari1,2, Nazanin Momeni Roudsari1,2, Hedieh Shamsnia1,2
1Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Advances in experimental medicine and biology
|June 28, 2023
概括
类药物具有抗炎性质,可能有助于治疗COVID-19. 本综述探讨了它们对抗SARS-CoV-2感染的潜在益处,通过检查它们对关键炎症通路的影响.
科学领域:
- * 免疫学和药理学
- * 传染病和治疗方法
背景情况:
- *由SARS-CoV-2引起的COVID-19具有很高的死亡率,炎症对其发病有很大影响.
- *像NF-κB,STAT,NLRP,TLRs,MAPK和mTOR这样的炎症通路,以及IL-6和TNF-α这样的媒介,驱动肺损伤和呼吸衰竭.
研究的目的:
- * 为了研究他类药物的抗炎作用.
- * 评估他类药物在治疗COVID-19中的潜在治疗益处.
主要方法:
- * 实验和临床研究的综合文献综述.
- *数据来自谷歌学者,PubMed,Scopus和科克兰图书馆.
- *1998年至2022年10月以英语出版的研究.
主要成果:
- * 类他类药物以其降胆固醇效应而闻名.
- * 类他类药物表现出显著的类型抗炎作用.
- * 这些抗炎性质表明在治疗COVID-19方面具有潜在的有效性.
结论:
- * 类药物的抗炎作用为COVID-19治疗提供了一个有前途的途径.
- *需要进一步研究他类药物在减轻SARS-CoV-2引起的炎症中的作用.
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