在慢性淋巴细胞白血病患者中评估第二次原发性癌症风险:多中心研究
Selim Sayin1, Emrah Kiliacslan2, Murat Yildirim1
1Gülhane Educational and Research Hospital, Department of Hematology, Ankara, Turkey.
Asian Pacific journal of cancer prevention : APJCP
|June 28, 2023
概括
患有慢性淋巴细胞白血病 (CLL) 的患者患第二次原发性癌症 (SPC) 的风险为9.2%,特别是上皮瘤. 在患有SPC的CLL患者中,13q删除遗传异常明显更常见.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
背景情况:
- 患有慢性淋巴细胞白血病 (CLL) 的患者面临第二次原发性癌症 (SPC) 的风险增加.
- 了解CLL中SPC的发病率和风险因素对于患者管理至关重要.
研究的目的:
- 为了确定CLL患者SPC的频率.
- 调查SPC与治疗状态,细胞遗传因素和其他风险因素之间的关系.
主要方法:
- 多中心,回顾性研究设计.
- 涉及553名被诊断患有CLL的患者.
- 2016年8月至2021年5月期间收集的数据.
主要成果:
- 在553名CLL患者中,在51名患者中观察到9.2%的SPC发病率.
- 表皮瘤是最常见的SPC,其次是皮肤,淋巴瘤和癌.
- 13q删除是最常见的遗传异常,在SPC患者中发现的异常明显更频繁.
结论:
- 在CLL中SPC的更高率与诊断时的年龄,13q删除,CD38阳性以及用fludarabine和单克隆抗体治疗有关.
- SPC风险独立于大多数遗传突变 (13q除外),血液图值 (血红蛋白除外) 和治疗线.
- 患有SPC的CLL患者的死亡率较高,并且在更晚的阶段被诊断出来.
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