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用口服直接作用抗病毒剂治疗的HCV诱导患者的B细胞克隆性

Basma Waly¹, Mohammed Taha Abdel-Aal², Shahira El-Etreby¹

¹Specialized Medical hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Asian Pacific journal of cancer prevention : APJCP

|June 28, 2023

概括

埃及的C型肝炎病毒 (HCV) 感染与B细胞异常有关. 直接作用抗病毒疗法 (DAA) 部分降低了这些标记物,这表明IgH重组可以预测淋巴增殖性疾病.

科学领域:

免疫学免疫学免疫学
肝病学肝病学是一种肝病学.
在瘤学瘤学.

背景情况:

肝炎C病毒 (HCV) 构成了全球卫生挑战,埃及的患病率高 (14.7%).
冠状病毒感染可以影响B淋巴细胞,可能导致单克隆B细胞扩张,这是免疫球蛋白重链 (IgH) 基因重组所表明的.
评估埃及HCV患者的IgH重组对于了解疾病机制和治疗反应至关重要.

研究的目的:

确定埃及慢性HCV患者IgH基因重组的患病率.
研究口服直接作用抗病毒疗法 (DAA) 对IgH克隆性标记物的回归的影响.

主要方法:

该研究包括78名被诊断患有慢性HCV感染的埃及患者.
根据BIOMED-2国际指导方针,采用聚合酶链反应 (PCR) 分析来检测IgH重组.
分析将IgH克隆性与病毒载量,肝酶和淋巴增殖性疾病 (LPD) 的存在相关联.

主要成果:

在克隆IgH患者中观察到HCV-RNA和阿氨酸转胺酶 (ALT) 水平的显著增加.
卡帕和兰巴自由光链水平仅在患有LPD的克隆IgH患者中显著增加.
在37.17%的患者中检测到IgH克隆性 (7.69%患有LPD,29.48%没有LPD).
在DAA治疗和HCV根除后,37%的检测到的IgH克隆性消失了.

结论:

有或没有利巴维林 (RBV) 的DAA疗法对于治疗埃及HCV患者是安全有效的.
DAA疗法部分,但不是完全,消除IgH克隆性.
IgH重新排列是预测慢性HCV患者的LPD风险的有价值指标.

关键词:

克隆性克隆性是指克隆性一个DAA就是DAA.在HCV病毒感染的过程中,在IgH重新排列的过程中.在LPD中,LPD是指LPD.

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