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患有过高甘油三血症和相关的急性胰腺炎的患者中早期的等离子酶
Longxiang Cao1,2, Yingjie Chen3,4, Siyao Liu5
1Department of Critical Care Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
JAMA network open
|June 28, 2023
概括
血酶不会改善与高甘油三血症相关的急性胰腺炎 (HTG-AP) 的结果. 这种治疗没有减少器官衰竭,但在HTG-AP患者中增加了重症监护室 (ICU) 的入院.
科学领域:
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
- 心血管医学 心血管医学
背景情况:
- 与高甘油三血症相关的急性胰腺炎 (HTG-AP) 是一个越来越令人担忧的问题.
- 血酶是一种潜在的HTG-AP治疗方法,旨在降低甘油三水平,但其临床有效性仍然不确定.
研究的目的:
- 评估血酶与被诊断为HTG-AP的患者器官衰竭的发生和持续时间之间的关联.
主要方法:
- 一项多中心前性队列研究分析了267名HTG-AP患者的数据.
- 倾向分数匹配 (PSM) 和治疗权重的逆概率 (IPTW) 用于控制混因素.
- 主要结局是入学14天内没有器官衰竭的日子.
主要成果:
- 与传统治疗相比,血酶与无器官衰竭日的显著差异没有关联 (P=.94).
- 接受血酶治疗的患者在重症监护室 (ICU) 的入院率明显更高 (93.6%与51.1%,P<.001).
- IPTW的分析证实了PSM的发现.
结论:
- 在患有HTG-AP的患者中,虽然用于降低甘油三,但血酶在减少器官衰竭方面没有显示出益处.
- 在HTG-AP中使用等离子酶与ICU资源利用率的增加有关.
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