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最近在体外皮肤芯片模型中取得的进展,用于药物测试

Jong Hwan Sung1, Jae Jung Kim1

  • 1Department of Chemical Engineering, Hongik University, Seoul, Republic of Korea.

Expert opinion on drug metabolism & toxicology
|June 28, 2023
PubMed
概括

在生理学上现实的体外皮肤模型对于了解皮肤疾病和与其他器官的相互作用至关重要. 器官芯片技术推动了这些模型的发展,有助于制药发展.

关键词:
药物代谢 药物代谢人类皮肤 人类皮肤多器官在芯片上的多器官器官在芯片上的器官皮肤疾病 皮肤疾病在芯片上的皮肤.

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Methods for Studying Drug Absorption: In vitro01:16

Methods for Studying Drug Absorption: In vitro

In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
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