作为监测工具的西班牙阿片类药物处方和阿片类药物相关死亡率之间的相关性:生态研究研究
Alejandro Salazar1,2,3, Soledad Moreno-Pulido4, Pablo Prego-Meleiro5,6
1Observatory of Pain, University of Cádiz, Cádiz, Spain.
西班牙的阿片类药物处方与阿片类药物相关死亡率 (ORM) 的增加相关. 这凸显了需要更严格的处方指南,以减少死亡.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在西班牙,阿片类药物处方 (ODP) 和阿片类药物相关死亡率 (ORM) 正在上升.
- ORM数据往往没有区分合法和非法阿片类药物类型.
研究的目的:
- 调查西班牙ODP和ORM之间的相关性.
- 评估ODP和ORM数据作为公共卫生监测工具的有用性.
主要方法:
- 一项生态研究分析了2000-2019年间的回顾性年度数据.
- 阿片类药物处方数据 (DHD) 来自西班牙药品管理局.
- 与阿片类药物相关的死亡率数据是根据ICD-10代码从国家统计局获得的.
主要成果:
- ORM率在百万分之一的14-23人死亡之间,自2010年以来一直呈上升趋势.
- 在ORM和总ODP (r=0.597;P=.006) 之间发现了显著的正相关性,以及不含可代因/特拉马多尔的ODP (r=0.934;P<.001).
- 在同一年内观察到相关性,尽管并不总是统计学上显著.
结论:
- 处方阿片类药物的可用性增加与阿片类药物相关死亡人数的增加有关.
- ODP-ORM相关性可以作为对合法阿片类药物和潜在的非法市场问题的监视工具.
- 对非标签处方采取更严格的措施是必要的,以制与阿片类药物有关的死亡.
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