[与基于蛋白激酶抑制剂的皮肤黑色素瘤治疗相关的双边脑膜炎 (案例研究) ]
E V Udovichenko1, L P Danilova1,2, E L Sorokin1,3
1Khabarovsk branch of S.N. Fedorov Eye National Medical Research Center "MNTK "Eye Microsurgery", Khabarovsk, Russia.
Vestnik oftalmologii
|June 28, 2023
概括
长期使用维穆拉菲尼布治疗可能会导致双边卵膜炎与黄斑. 虽然皮质类固醇可以提供暂时的缓解,但只有停止使用维穆拉费尼布才能提供持久的缓解,这凸显了眼科医生监测的必要性.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 维穆拉菲尼布是一种有效的癌症治疗方法,但可能会导致有毒的副作用.
- 眼部并发症,如眼膜炎和黄斑,是潜在的不良事件.
- 长期使用向疗法需要对系统性和局部性毒性进行仔细监测.
研究的目的:
- 在长期治疗维穆拉菲尼布期间报告双边卵膜炎与黄斑的临床病例.
- 为了评估保守治疗维穆拉费尼布诱导的眼睛并发症的疗效.
- 强调多学科合作在治疗长期服用维穆拉费尼布的患者管理中的重要性.
主要方法:
- 一个病人的病例报告,该病患患有双边卵膜炎和黄斑.
- 用于缓解症状的皮质类固醇的管理.
- 停止使用维穆拉费尼布,以评估治疗反应.
- 临床观察和随访由瘤学家和眼科医生进行.
主要成果:
- 在长期治疗维穆拉菲尼布期间,出现双边膜炎与斑点.
- 皮质类固醇治疗提供了暂时的改善,但与复发有关.
- 完全停止使用维穆拉费尼布导致眼部症状的持续缓解.
- 这一案例与先前的临床观察结果一致,这些临床观察结果显示了因韦穆拉芬尼布引起的眼睛毒性.
结论:
- 维穆拉菲尼布可以引起严重的眼部并发症,如卵膜炎和黄斑.
- 眼科监测对于接受长期维穆拉菲尼布治疗的患者至关重要.
- 瘤学家和眼科医生之间的合作护理对于预防严重的视力障碍至关重要.
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