维生素D状况和与老年人炎症的关联
Eamon Laird1,2, Aisling M O'Halloran3, Anne M Molloy2
1School of Physical Education and Sports Science, University of Limerick, Limerick, Ireland.
PloS one
|June 28, 2023
概括
患有维生素D缺乏症的老年人表现出较高的炎症标志物,特别是C反应蛋白 (CRP). 优化维生素D水平可能有助于减少这种人群的炎症和慢性疾病风险.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 维生素D与炎症的关联已被注意到,但对代表性老年人群的数据有限.
- 由C反应蛋白 (CRP) 表示的炎症是与年龄相关的慢性疾病的关键因素.
研究的目的:
- 在一个代表性老年爱尔兰成年人样本中调查维生素D状态和CRP水平之间的关系.
- 为了确定维生素D状态是否影响50岁及以上社区居民的炎症标志物.
主要方法:
- 对来自爱尔兰老龄化纵向研究 (TILDA) 的5381名参与者的25-基维生素D (25(OH) D) 和CRP度的分析.
- 利用多名义物流回归来评估25~OH) D和CRP状态之间的关联,控制人口统计,健康和生活方式变量.
主要成果:
- 正常CRP (0-5毫克/分升) 的患病率为83.9%,升高 (5-10毫克/分升) 为11.0%,高 (>10毫克/分升) 为5.1%.
- 与缺乏维生素D状态的人相比,正常维生素D状态的个体中CRP平均度明显较低 (2.02 mg/dL对比2.60 mg/dL,p<0.0001).
- 缺乏或足够25(OH) D状态的个体与缺乏状态的人相比,CRP水平较高的可能性较小 (分别p<0.0001和p=0.001).
结论:
- 老年人缺乏维生素D的状况与CRP测量的炎症升高有关.
- 优化维生素D水平是一个潜在的低风险,低成本的策略,用于管理老年人的炎症.
- 通过维生素D调节炎症可以减轻与衰老相关的慢性疾病的病理驱动因素.
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