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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Two-step Approach to Explore Early- and Late-stages of Organ Formation in the Avian Model: The Thymus and Parathyroid Glands Organogenesis Paradigm
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功能性敏感的副甲状腺,使用单阶段胚胎细胞补充生成.

Mayuko Kano1,2,3, Naoaki Mizuno1,2, Hideyuki Sato1,2

  • 1Stem Cell Therapy Laboratory, Advanced Research Institute, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo 113-8510, Japan.

Proceedings of the National Academy of Sciences of the United States of America
|June 28, 2023
PubMed
概括
此摘要是机器生成的。

胚胎囊补充成功地从小鼠干细胞生成了功能性副甲状腺. 这种方法提供了一种有前途的新策略,用于治疗缺甲状腺症和恢复平衡.

关键词:
甲状腺装置鼠标的小鼠胚胎囊的补充作用胚胎干细胞是一种胚胎干细胞.甲状腺上下的情况副甲状腺腺体 副甲状腺体

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科学领域:

  • 内分泌学 在内分泌学.
  • 发展生物学 发展生物学
  • 再生医学是一种再生医学.

背景情况:

  • 永久性偏偏甲状腺症需要终身治疗,有效性有限.
  • 目前的实验室干细胞衍生副甲状腺细胞缺乏重要的感应功能.
  • 功能性副甲状腺移植是一种潜在的替代方案,可以改善患者的治疗结果.

研究的目的:

  • 作为产生功能性副甲状腺 (PTG) 的策略,研究胚胎囊补充 (BC).
  • 评估BC衍生的PTGs在低甲状腺模型中恢复平衡的潜力.
  • 探索跨物种PTG生成对未来人类治疗应用的可行性.

主要方法:

  • 使用CRISPR-Cas9敲除*缺失的质细胞2* (*Gcm2*) 的甲状腺腺小鼠胚胎的生成.
  • 使用小鼠胚胎干细胞 (mESCs) 来产生PTG的胚胎细胞补充.
  • 将mESC衍生的PTG移植到*Gcm2*淘汰赛小鼠和外科手术下巴甲状腺小鼠中.
  • 在 *Gcm2* 淘汰赛老鼠新生儿中,物种间的胚胎细胞补充.

主要成果:

  • 从mESC中通过单步BC产生完全功能性的PTG.
  • 由mESC衍生的PTG分化,成熟,并从新生儿死亡中拯救*Gcm2*敲杀小鼠.
  • 移植的mESC衍生的PTGs对细胞外有反应,并恢复了平衡.
  • 在老鼠新生儿中成功生成了功能性物种间PTG.

结论:

  • 胚胎囊补充是一种生产功能性内分泌器官,特别是PTG的可行方法.
  • 这种方法为治疗永久性偏偏甲状腺症提供了一个新的概念.
  • 跨物种BC有潜力开发用于未来人类副甲状腺治疗的异种动物模型.