在异性干细胞移植后的和阴道移植与宿主疾病对比-一项系统性审查
Marta Preston1, Anthony Richards
1Obstetrics and Gynaecology Department, Sunshine Hospital, Western Health, St Albans, Victoria, Australia.
Journal of lower genital tract disease
|June 28, 2023
概括
女性生殖器移植对宿主疾病 (GVHD) 在干细胞移植后很罕见. 早期的妇科护理对于控制症状和预防宫发育不良等长期并发症至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 妇科 妇科医生 妇科
背景情况:
- 移植与宿主疾病 (GVHD) 可以影响各种各样的器官在异质干细胞移植后.
- 和阴道GVHD是需要专注的临床关注的特定表现.
研究的目的:
- 系统地审查关于和阴道GVHD的文献.
- 确定女性生殖器GVHD的患病率,临床表现和管理策略.
主要方法:
- 从1993年到2022年8月进行系统的文献搜索.
- 包括关于女性受试者 (≥5名患者) 的全文英语文章的研究.
- 排除病例报告,病例系列 (<5名患者),评论和会议摘要.
主要成果:
- 29项研究符合纳入标准,并指出存在偏差的高风险.
- 在移植后,和阴道GVHD的患病率在27%至66%之间.
- 同时在其他器官GVHD是常见的;患者可能无症状. 治疗包括局部疗法,扩张和耐火病例的手术. 宫发育不良的风险增加需要进行HPV查.
结论:
- 女性生殖器GVHD是一种罕见但显著的并发症.
- 定期,协调的妇科检查对于早期检测和管理至关重要.
- 主动管理可以减轻长期并发症,改善患者的治疗结果.
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